Rücktitelbild: Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo (Angew. Chem. 27/2013)

Authors

  • Dr. Tae Hyung Kim,

    1. Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University, 400 North Broadway, Baltimore, MD 21231 (USA)
    2. College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-gu, Suwon 440-746 (Korea)
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  • Dr. Magdalena Swierczewska,

    1. Institute for NanoBioTechnology, Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Johns Hopkins University (USA)
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  • Dr. Yumin Oh,

    1. Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University, 400 North Broadway, Baltimore, MD 21231 (USA)
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  • Dr. AeRyon Kim,

    1. Department of Pathology, Johns Hopkins University (USA)
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  • Prof. Dr. Dong Gyu Jo,

    1. College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-gu, Suwon 440-746 (Korea)
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  • Prof. Dr. Jae Hyung Park,

    1. Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon (Korea)
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  • Prof. Dr. Youngro Byun,

    1. College of Pharmacy, Seoul National University, Seoul (Korea)
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  • Prof. Dr. Scheherazade Sadegh-Nasseri,

    1. Department of Pathology, Johns Hopkins University (USA)
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  • Prof. Dr. Martin G. Pomper,

    1. Institute for NanoBioTechnology, Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Johns Hopkins University (USA)
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  • Prof. Dr. Kang Choon Lee,

    Corresponding author
    1. College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-gu, Suwon 440-746 (Korea)
    • Kang Choon Lee, College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-gu, Suwon 440-746 (Korea)

      Seulki Lee, Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University, 400 North Broadway, Baltimore, MD 21231 (USA)

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  • Prof. Dr. Seulki Lee

    Corresponding author
    1. Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University, 400 North Broadway, Baltimore, MD 21231 (USA)
    • Kang Choon Lee, College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-gu, Suwon 440-746 (Korea)

      Seulki Lee, Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University, 400 North Broadway, Baltimore, MD 21231 (USA)

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Abstract

original image

Eine verlängerte Halbwertszeit für therapeutische Proteine sollte die Suche nach neuen Proteinwirkstoffen erleichtern. In ihrer Zuschrift auf S. 7018 ff. beschreiben K. C. Lee, S. Lee und Mitarbeiter einen Weg zu diesem Ziel: Sie haben eine spezifische und zuverlässige Methode entwickelt, bei der sie erst Ni-NTA an Polyethylenglycol konjugieren und dann an Oligohistidin-markierte therapeutische Proteine binden, um deren Stabilität in vivo zu erhöhen, ohne die biologische Aktivität zu beeinträchtigen.

Cartoon 1.

Ancillary