Formation of a Dinuclear Copper(I) Complex from the Clostridium-Derived Antibiotic Closthioamide

Authors

  • Dipl.-Chem. Florian Kloss,

    1. Leibniz Institute for Natural Product Research and Infection Biology, HKI, Dept. of Biomolecular Chemistry, Beutenbergstr. 11a, 07745 Jena (Germany)
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  • Dr. Sacha Pidot,

    1. Leibniz Institute for Natural Product Research and Infection Biology, HKI, Dept. of Biomolecular Chemistry, Beutenbergstr. 11a, 07745 Jena (Germany)
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  • Dr. Helmar Goerls,

    1. Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University, Humboldtstr. 8, 07743 Jena (Germany)
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  • Prof. Dr. Thorsten Friedrich,

    1. Institute for Biochemistry, University of Freiburg, Albertstr. 21, 79104 Freiburg i. Br. (Germany)
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  • Prof. Dr. Christian Hertweck

    Corresponding author
    1. Leibniz Institute for Natural Product Research and Infection Biology, HKI, Dept. of Biomolecular Chemistry, Beutenbergstr. 11a, 07745 Jena (Germany)
    2. Chair of Natural Product Chemistry, Friedrich Schiller University, Jena (Germany)
    • Leibniz Institute for Natural Product Research and Infection Biology, HKI, Dept. of Biomolecular Chemistry, Beutenbergstr. 11a, 07745 Jena (Germany)
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  • We thank S. Behnken for initial biological studies, A. Perner for MS analyses, H. Heinecke for NMR measurements, Uwe Knüpfer for support in fermentations, and Dr. T. Wichard (FSU) for initial UPLC method development. This work was supported by the “Pakt für Forschung und Innovation” of the Free State of Thuringia and the Federal Ministry of Science and Technology (BMBF (Germany)), and the International Leibniz Research School for Biomolecular and Microbial Interactions (ILRS), as part of the excellence graduate school Jena School for Microbial Communication (JSMC).

Abstract

original image

Ein Chelatbildner aus der sauerstofffreien Welt: Verschiedenste Experimente zeigen, dass Closthioamid, das erste Antibiotikum aus einem streng anaeroben Bakterium (Clostridium), ein selektiver Kupfer(I)-Chelatbildner ist. Die Geometrie des Polythioamid-Komplexes, in dem zwei Kupferionen in einer trigonal-planaren Koordination die Windung einer Helix-artigen Struktur stabilisieren, ist für Naturstoffe beispiellos.

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