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Base-Catalyzed Electrophilic Trifluoromethylthiolation of Terminal Alkynes

Authors

  • Sébastien Alazet,

    1. Institute of Chemistry and Biochemistry (ICBMS—UMR CNRS 5246), Université de Lyon, Université Lyon 1, CNRS, 43 Bd du 11 novembre 1918, 69622 Lyon (France)
    2. CERMEP—in vivo imaging, Groupement Hospitalier Est, 59 Bd Pinel, 69003 Lyon (France)
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  • Prof. Luc Zimmer,

    1. CERMEP—in vivo imaging, Groupement Hospitalier Est, 59 Bd Pinel, 69003 Lyon (France)
    2. Lyon Neuroscience Research Center (UMR CNRS 5292, UMR INSERM 1028), Groupement Hospitalier Est, 59 Bd Pinel, 69003 Lyon (France)
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  • Dr. Thierry Billard

    Corresponding author
    1. Institute of Chemistry and Biochemistry (ICBMS—UMR CNRS 5246), Université de Lyon, Université Lyon 1, CNRS, 43 Bd du 11 novembre 1918, 69622 Lyon (France)
    2. CERMEP—in vivo imaging, Groupement Hospitalier Est, 59 Bd Pinel, 69003 Lyon (France)
    • Institute of Chemistry and Biochemistry (ICBMS—UMR CNRS 5246), Université de Lyon, Université Lyon 1, CNRS, 43 Bd du 11 novembre 1918, 69622 Lyon (France)
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  • We thank the CNRS and the French Ministry of Research for their financial supports. The French Fluorine Network is also thanked for its support.

Abstract

original image

Einfach und schnell können CF3S- oder CF3CF2S-Alkine erhalten werden, indem man terminale Alkine mit einem Trifluormethansulfenamid-Reagens mischt. Die Reaktion verwendet leicht handhabbare Reagentien und funktioniert unter milden Bedingungen ohne Aktivierung durch Übergangsmetalle.

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