Plasmonic Nanoprobes for Real-Time Optical Monitoring of Nitric Oxide inside Living Cells

Authors

  • Dr. Pilar Rivera_Gil,

    1. Department of Physics, Philipps Universität Marburg, 35037 Marburg (Germany)
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    • These authors contributed equally to this work.

  • Carmen Vazquez-Vazquez,

    1. Department of Physical Chemistry, University of Vigo, 36310 Vigo (Spain)
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    • These authors contributed equally to this work.

  • Dr. Vincenzo Giannini,

    1. Department of Physics, Imperial College London, London SW7 2AZ (UK)
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  • Prof. M. Pilar Callao,

    1. Department of Chemistry, Universitat Rovira i Virgili, 43007 Tarragona (Spain)
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  • Prof. Wolfgang J. Parak,

    Corresponding author
    1. Department of Physics, Philipps Universität Marburg, 35037 Marburg (Germany)
    • Wolfgang J. Parak, Department of Physics, Philipps Universität Marburg, 35037 Marburg (Germany)

      Miguel A. Correa-Duarte, Department of Physical Chemistry, University of Vigo, 36310 Vigo (Spain)

      Ramon A. Alvarez-Puebla, Department of Chemistry, Universitat Rovira i Virgili, 43007 Tarragona (Spain)

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  • Prof. Miguel A. Correa-Duarte,

    Corresponding author
    1. Department of Physical Chemistry, University of Vigo, 36310 Vigo (Spain)
    • Wolfgang J. Parak, Department of Physics, Philipps Universität Marburg, 35037 Marburg (Germany)

      Miguel A. Correa-Duarte, Department of Physical Chemistry, University of Vigo, 36310 Vigo (Spain)

      Ramon A. Alvarez-Puebla, Department of Chemistry, Universitat Rovira i Virgili, 43007 Tarragona (Spain)

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  • Prof. Ramon A. Alvarez-Puebla

    Corresponding author
    1. Department of Chemistry, Universitat Rovira i Virgili, 43007 Tarragona (Spain)
    2. ICREA (Catalonian Institution for Research and Advanced Studies), Avda. Lluís Companys, 08010 Barcelona (Spain)
    3. Center for Chemical Technology of Catalonia, Edifici N5, Carrer de Marcel⋅lí Domingo, s/n 43007 Tarragona (Spain)
    • Wolfgang J. Parak, Department of Physics, Philipps Universität Marburg, 35037 Marburg (Germany)

      Miguel A. Correa-Duarte, Department of Physical Chemistry, University of Vigo, 36310 Vigo (Spain)

      Ramon A. Alvarez-Puebla, Department of Chemistry, Universitat Rovira i Virgili, 43007 Tarragona (Spain)

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  • This work was funded by the Spanish Ministerio de Economía y Competitividad (CTQ2011-23167), the European Research Council (CrossSERS, FP7/2013 329131, Metachem FP7/2008 228762-2), and the Human Frontier Science Program (grant RGP0052/2012-C201). We also acknowledge Niurka Llópiz Janer for her help with the cellular cultures.

Abstract

original image

Ein optischer Sensor wurde für die quantitative Bestimmung von intrazellulärem Stickstoffmonoxid entwickelt. Der Sensor besteht aus plasmonischen Nanosonden (siehe Bild, links) mit einer Ummantelung aus mesoporösen Silicaten und im Innern einem Film aus Goldinseln, die mit einem Chemorezeptor für NO funktionalisiert sind.

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