Enantioselective Palladium(II) Phosphate Catalyzed Three-Component Reactions of Pyrrole, Diazoesters, and Imines

Authors

  • Dan Zhang,

    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai 200062 (China)
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  • Huang Qiu,

    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai 200062 (China)
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  • Dr. Liqin Jiang,

    Corresponding author
    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai 200062 (China)
    • Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai 200062 (China)===

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  • Fengping Lv,

    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai 200062 (China)
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  • Chaoqun Ma,

    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai 200062 (China)
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  • Prof. Dr. Wenhao Hu

    Corresponding author
    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai 200062 (China)
    • Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai 200062 (China)===

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  • We are grateful for financial support from the NSFC (21002033, 20932003, and 21125209), the Ministry of Science and Technology (MOST) of China (2011CB808600), and STCSM of Shanghai (12JC1403800).

Abstract

original image

Reaktionstrio: Die Titelreaktion ergibt C-H-funktionalisierte Pyrrolderivate in mäßigen bis guten Ausbeuten; sowohl die syn- als auch die anti-Produkte mit zwei benachbarten Stereozentren sind mit guten Regio-, Diastereo- und Enantioselektivitäten zugänglich. Der Prozess ist die erste hoch enantioselektive Palladiumcarbenoid-vermittelte Reaktion.

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