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Kinetic Resolution of Axially Chiral 2-Amino-1,1′-Biaryls by Phase-Transfer-Catalyzed N-Allylation

Authors

  • Dr. Seiji Shirakawa,

    1. Laboratory of Synthetic Organic Chemistry and Special Laboratory of Organocatalytic Chemistry, Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502 (Japan)
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  • Xiangfei Wu,

    1. Laboratory of Synthetic Organic Chemistry and Special Laboratory of Organocatalytic Chemistry, Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502 (Japan)
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  • Prof. Dr. Keiji Maruoka

    Corresponding author
    1. Laboratory of Synthetic Organic Chemistry and Special Laboratory of Organocatalytic Chemistry, Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502 (Japan)
    • Laboratory of Synthetic Organic Chemistry and Special Laboratory of Organocatalytic Chemistry, Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502 (Japan)

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  • This work was partially supported by a Grant-in-Aid for Scientific Research from the JSPS and MEXT (Japan). X.W. thanks the China Scholarship Council for a research fellowship.

Abstract

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Produktive Phase: Die selektive kinetische Racematspaltung der Titelverbindungen, die wichtige chirale Bausteine sind, wurde durch phasentransferkatalysierte N-Allylierung erreicht. Die Synthesemethode wurde auf die hoch enantioselektive Desymmetrisierung einer Biarylverbindung angewendet.

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