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Biodegradable Gold Nanovesicles with an Ultrastrong Plasmonic Coupling Effect for Photoacoustic Imaging and Photothermal Therapy

Authors

  • Dr. Peng Huang,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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    • These authors contributed equally.

  • Dr. Jing Lin,

    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
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    • These authors contributed equally.

  • Dr. Wanwan Li,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • Pengfei Rong,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • Dr. Zhe Wang,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
    2. Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361005 (China)
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  • Dr. Shouju Wang,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • Xiaoping Wang,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • Dr. Xiaolian Sun,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • Dr. Maria Aronova,

    1. Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB, National Institutes of Health (USA)
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  • Dr. Gang Niu,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • Prof. Richard D. Leapman,

    1. Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB, National Institutes of Health (USA)
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  • Prof. Zhihong Nie,

    Corresponding author
    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
    • Zhihong Nie, Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)

      Xiaoyuan Chen, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)

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  • Prof. Xiaoyuan Chen

    Corresponding author
    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
    • Zhihong Nie, Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)

      Xiaoyuan Chen, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)

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  • This research was supported by the startup funds of the University of Maryland, the Intramural Research Program (IRP) of the NIBIB, the NIH, the National Key Basic Research Program (973 Project; 2010CB933901, 2013CB733802, 2014CB744503), the National Science Foundation of China (81272987, 31170961, 51102258, 81371596), and a Chinese Academy of Sciences Professorship for Senior International Scientists (2011T2J06).

Abstract

The hierarchical assembly of gold nanoparticles (GNPs) allows the localized surface plasmon resonance peaks to be engineered to the near-infrared (NIR) region for enhanced photothermal therapy (PTT). Herein we report a novel theranostic platform based on biodegradable plasmonic gold nanovesicles for photoacoustic (PA) imaging and PTT. The disulfide bond at the terminus of a PEG-b-PCL block-copolymer graft enables dense packing of GNPs during the assembly process and induces ultrastrong plasmonic coupling between adjacent GNPs. The strong NIR absorption induced by plasmon coupling and very high photothermal conversion efficiency (η=37 %) enable simultaneous thermal/PA imaging and enhanced PTT efficacy with improved clearance of the dissociated particles after the completion of PTT. The assembly of various nanocrystals with tailored optical, magnetic, and electronic properties into vesicle architectures opens new possibilities for the construction of multifunctional biodegradable platforms for biomedical applications.

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