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Point Decoration of Silicon Nanowires: An Approach Toward Single-Molecule Electrical Detection

Authors

  • Jindong Wang,

    1. School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (P. R. China)
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    • These authors contributed equally to this work.

  • Fangxia Shen,

    1. State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Science and Engineering, Peking University, Beijing 100871 (P.R. China)
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    • These authors contributed equally to this work.

  • Zhenxing Wang,

    1. Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China)
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  • Gen He,

    1. Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China)
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  • Jinwen Qin,

    1. Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China)
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  • Nongyi Cheng,

    1. Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China)
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  • Prof. Maosheng Yao,

    Corresponding author
    1. State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Science and Engineering, Peking University, Beijing 100871 (P.R. China)
    • Maosheng Yao, State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Science and Engineering, Peking University, Beijing 100871 (P.R. China)===

      Lidong Li, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (P. R. China)===

      Xuefeng Guo, Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China)===

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  • Prof. Lidong Li,

    Corresponding author
    1. School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (P. R. China)
    • Maosheng Yao, State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Science and Engineering, Peking University, Beijing 100871 (P.R. China)===

      Lidong Li, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (P. R. China)===

      Xuefeng Guo, Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China)===

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  • Prof. Xuefeng Guo

    Corresponding author
    1. Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China)
    • Maosheng Yao, State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Science and Engineering, Peking University, Beijing 100871 (P.R. China)===

      Lidong Li, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (P. R. China)===

      Xuefeng Guo, Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P.R. China)===

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  • We acknowledge primary financial support from NSFC (21225311, 51121091, 21373014, 91333102, 21003002, 21277007, and 41121004) and MOST (2012CB921404).

Abstract

Probing interactions of biological systems at the molecular level is of great importance to fundamental biology, diagnosis, and drug discovery. A rational bioassay design of lithographically integrating individual point scattering sites into electrical circuits is capable of realizing real-time, label-free biodetection of influenza H1N1 viruses with single-molecule sensitivity and high selectivity by using silicon nanowires as local reporters in combination with microfluidics. This nanocircuit-based architecture is complementary to more conventional optical techniques, but has the advantages of no bleaching problems and no fluorescent labeling. These advantages offer a promising platform for exploring dynamics of stochastic processes in biological systems and gaining information from genomics to proteomics to improve accurate molecular and even point-of-care clinical diagnosis.

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