This work was supported by the Singapore National Research Foundation (CREATE Programme of Nanomaterials for Energy and Water Management and NRF-RF2009-04).
A Synergistic Capture Strategy for Enhanced Detection and Elimination of Bacteria†
Article first published online: 19 MAR 2014
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 126, Issue 23, pages 5947–5951, June 2, 2014
How to Cite
Li, Y.-Q., Zhu, B., Li, Y., Leow, W. R., Goh, R., Ma, B., Fong, E., Tang, M. and Chen, X. (2014), A Synergistic Capture Strategy for Enhanced Detection and Elimination of Bacteria. Angew. Chem., 126: 5947–5951. doi: 10.1002/ange.201310135
- Issue published online: 30 MAY 2014
- Article first published online: 19 MAR 2014
- Manuscript Revised: 23 JAN 2014
- Manuscript Received: 21 NOV 2013
- Singapore National Research Foundation. Grant Number: NRF-RF2009-04
- Antimikrobielle Agentien;
Despite the advanced detection and sterilization techniques available today, the sensitive diagnosis and complete elimination of bacterial infections remain a significant challenge. A strategy is reported for efficient bacterial capture (ca. 90 %) based on the synergistic effect of the nanotopography and surface chemistry of the substrate on bacterial attachment and adhesion. The outstanding bacterial-capture capability of the functionalized nanostructured substrate enables rapid and highly sensitive bacterial detection down to trace concentrations of pathogenic bacteria (10 colony-forming units mL−1). In addition, this synergistic biocapture substrate can be used for efficient bacterial elimination and shows great potential for clinical antibacterial applications.