This work was supported by grants from the NIH (Grants EB014277 and GM077173.
Fabrication of Multiresponsive Bioactive Nanocapsules through Orthogonal Self-Assembly†
Article first published online: 1 APR 2014
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 126, Issue 20, pages 5237–5241, May 12, 2014
How to Cite
Yeh, Y.-C., Tang, R., Mout, R., Jeong, Y. and Rotello, V. M. (2014), Fabrication of Multiresponsive Bioactive Nanocapsules through Orthogonal Self-Assembly. Angew. Chem., 126: 5237–5241. doi: 10.1002/ange.201400559
- Issue published online: 8 MAY 2014
- Article first published online: 1 APR 2014
- Manuscript Received: 18 JAN 2014
- NIH. Grant Numbers: EB014277, GM077173
- Nichtkovalente Wechselwirkungen;
- Responsive Freisetzung;
Multifunctional self-assembled systems present platforms for fundamental research and practical applications as they provide tunability of structure, functionality, and stimuli responsiveness. Pragmatic structures for biological applications have multiple design requirements, including control of size, stability, and environmental response. Here we present the fabrication of multifunctional nanoparticle-stabilized capsules (NPSCs) by using a set of orthogonal supramolecular interactions. In these capsules, fluorescent proteins are attached to quantum dots through polyhistidine coordination. These anionic assemblies interact laterally with cationic gold nanoparticles that are anchored to the fatty acid core through guanidinium–carboxylate interactions. The lipophilic core then provides a reservoir for hydrophobic endosome-disrupting agents, thereby generating a system featuring stimuli-responsive release of a payload into the cytosol with fluorescence monitoring.