X.Y.L. thanks the National Research Foundation, Singapore (NRF-NRFF2012-04) for support and Nanyang Technological University for a start-up grant. H.K.L. thanks A*STAR, Singapore for an A*STAR Graduate Scholarship. SERS=surface-enhanced Raman spectroscopy.
Plasmonic Liquid Marbles: A Miniature Substrate-less SERS Platform for Quantitative and Multiplex Ultratrace Molecular Detection†
Article first published online: 1 APR 2014
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 126, Issue 20, pages 5154–5158, May 12, 2014
How to Cite
Lee, H. K., Lee, Y. H., Phang, I. Y., Wei, J., Miao, Y.-E., Liu, T. and Ling, X. Y. (2014), Plasmonic Liquid Marbles: A Miniature Substrate-less SERS Platform for Quantitative and Multiplex Ultratrace Molecular Detection. Angew. Chem., 126: 5154–5158. doi: 10.1002/ange.201401026
- Issue published online: 8 MAY 2014
- Article first published online: 1 APR 2014
- Manuscript Received: 30 JAN 2014
- National Research Foundation, Singapore. Grant Number: NRF-NRFF2012-04
- Nanyang Technological University
- A*STAR, Singapore
- Oberflächenverstärkte Raman-Spektroskopie;
Inspired by aphids, liquid marbles have been studied extensively and have found application as isolated microreactors, as micropumps, and in sensing. However, current liquid-marble-based sensing methodologies are limited to qualitative colorimetry-based detection. Herein we describe the fabrication of a plasmonic liquid marble as a substrate-less analytical platform which, when coupled with ultrasensitive SERS, enables simultaneous multiplex quantification and the identification of ultratrace analytes across separate phases. Our plasmonic liquid marble demonstrates excellent mechanical stability and is suitable for the quantitative examination of ultratrace analytes, with detection limits as low as 0.3 fmol, which corresponds to an analytical enhancement factor of 5×108. The results of our simultaneous detection scheme based on plasmonic liquid marbles and an aqueous–solid–organic interface quantitatively tally with those found for the individual detection of methylene blue and coumarin.