This work was partially supported by Innovation Technology Fund (ITS/066/09) and RGC-General Research Fund (201213). Prof. Guo-liang Shao, Department of Radiology, Zhejiang Cancer Hospital is gratefully acknowledged.
In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites†
Article first published online: 25 MAR 2014
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 126, Issue 19, pages 4912–4915, May 5, 2014
How to Cite
Wang, Y.-X. J., Zhu, X.-M., Liang, Q., Cheng, C. H. K., Wang, W. and Leung, K. C.-F. (2014), In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites. Angew. Chem., 126: 4912–4915. doi: 10.1002/ange.201402144
- Issue published online: 2 MAY 2014
- Article first published online: 25 MAR 2014
- Manuscript Received: 7 FEB 2014
- Innovation Technology Fund. Grant Number: ITS/066/09
- RGC-General Research Fund. Grant Number: 201213
A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an in vivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent.