Dedicated to Professor Karl Freudenberg on the occasion of his 80th birthday.
The Biosynthesis of Cyclitols†
Article first published online: 17 DEC 2003
Copyright © 1966 by Verlag Chemie, GmbH, Germany
Angewandte Chemie International Edition in English
Volume 5, Issue 2, pages 165–173, February 1966
How to Cite
Kindl, H., Scholda, R. and Hoffmann-Ostenhof, O. (1966), The Biosynthesis of Cyclitols. Angew. Chem. Int. Ed. Engl., 5: 165–173. doi: 10.1002/anie.196601651
- Issue published online: 17 DEC 2003
- Article first published online: 17 DEC 2003
- Manuscript Received: 4 JAN 1965
Information has recently been obtained, mainly with the aid of radioactive compounds, about the biosynthesis of various cyclitols. It was found that the most widely occurring cyclitol, meso-inositol, is biosynthesized by a pathway probably common to all organisms, in which the cyclohexane ring is formed by ring closure between the two terminal carbon atoms of D-glucose. Cell-free extracts or enzyme systems that catalyse the conversion of D-glucose into meso-inositol can be prepared from various biological materials. The biosynthesis of the other hexahydroxycyclohexanes (inositols) involves meso-inositol as an intermediate. A few steps in the conversion of meso-inositol into other inositols have been studied.