Detection of Hindered Rotation and Inversion by NMR Spectroscopy

Authors

  • Priv.-Doz. Dr. Horst Kessler

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    1. Chemisches Institut der Universität, 74 Tübingen, Wilhelmstrasse 33 (Germany)
    • Chemisches Institut der Universität, 74 Tübingen, Wilhelmstrasse 33 (Germany)
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  • Part 13 of a series of reports on the detection of intramolecular mobility by NMR spectroscopy. For Part 12 see [109].

Abstract

Rotations and inversions in organic molecules are readily recognizable from the temperature dependence of the NMR spectra. The study of the effects of substituents on the activation barriers of such processes permits the elucidation of reaction mechanisms, and the stability limits of isomers can also be determined. The knowledge of the stability limits is necessary for the specific synthesis of stable rotamers and invertomers.

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