Nucleosides and Nucleotides as Potential Therapeutic Agents

Authors

  • Dr. T. Y. Shen

    Corresponding author
    1. Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065 (USA)
    • Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065 (USA)
    Search for more papers by this author

Abstract

The present article summarizes recent progress in the study of nucleoside derivatives as antiviral and immunosuppressive agents. A number of 5′-substituted 5′-deoxy nucleosides have been found to be permeable and nonincorporable antimetabolites of 5′-nucleotides. N6-isopentenyladenosine and analogs show certain promising immunosuppressive activities. Encouraged by the antibody-stimulating effect of oligonucleotides, we have developed a convenient synthesis of oligonucleotides using fully protected phosphorylated intermediates. A group of tetradeoxyribonucleotides, dApdApdApdX, was prepared for biological and physical evaluations. Nucleotide derivatives may prove valuable in the treatment of several immunological disorders.

Ancillary