Most of the unpublished work cited by the author has been supported by the Deutsche Forschungsgemeinschaft.
Structure and Function of Ferritin†
Article first published online: 22 DEC 2003
Copyright © 1973 by Verlag Chemie, GmbH, Germany
Angewandte Chemie International Edition in English
Volume 12, Issue 1, pages 57–65, January 1973
How to Cite
Crichton, R. R. (1973), Structure and Function of Ferritin. Angew. Chem. Int. Ed. Engl., 12: 57–65. doi: 10.1002/anie.197300571
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- Manuscript Received: 11 JAN 1972
- Bioinorganic chemistry
Ferritin is the major iron storage protein of mammals and consists of up to 4500 atoms of ferric iron surrounded by a shell of protein subunits. The protein component, apoferritin, consists of 24 identical polypeptide chains each of molecular weight 18500. The function of ferritin is to store iron in a soluble form from which it can be readily mobilized. Recent results concerning the structure of the protein are reported, and progress in the elucidation of the mechanisms whereby iron is introduced into apoferritin and released from ferritin is reviewed.