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Absolute Configuration of the Cancerostatic S([BOND])-Cyclophosphamide

Authors

  • Dr. Dorota A. Adamaik,

    1. Abteilung Chemie, Max-Planck-Institut für Experimentelle Medizin Hermann-Rein-Strasse 3, D-3400 Göttingen (Germany)
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  • Dr. Ryszard Kinas,

    1. Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences Boczna 6, 90-362 Lodz (Poland)
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  • Priv.-Doz. Dr. Wolfram Saenger,

    Corresponding author
    1. Abteilung Chemie, Max-Planck-Institut für Experimentelle Medizin Hermann-Rein-Strasse 3, D-3400 Göttingen (Germany)
    • Abteilung Chemie, Max-Planck-Institut für Experimentelle Medizin Hermann-Rein-Strasse 3, D-3400 Göttingen (Germany)
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  • Dr. Wojciech J. Stec

    1. Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences Boczna 6, 90-362 Lodz (Poland)
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Abstract

original image

(+) and (−)-Cyclophosphamide(1) differ in their cancerostatic activity. X-Ray analysis has shown the (−)-enantiomer with the higher therapeutic index to have the S configuration.

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