A Cobalt-Catalyzed One-Step Synthesis of Annelated Pyridines

Authors

  • Alaric Naiman,

    Corresponding author
    1. Department of Chemistry, University of California, and the Materials and Molecular Research Division, Lawrence Berkeley Laboratory, Berkeley, California 94720 (USA)
    • Department of Chemistry, University of California, and the Materials and Molecular Research Division, Lawrence Berkeley Laboratory, Berkeley, California 94720 (USA)
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  • Dr. K. Peter C. Vollhardt

    1. Department of Chemistry, University of California, and the Materials and Molecular Research Division, Lawrence Berkeley Laboratory, Berkeley, California 94720 (USA)
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  • This work was supported by the National Institutes of Health (GM 22479), the National Science Foundation (CHE76-01783), (in part) by Cancer Research Funds of the University of California, and the A. P. Sloan Foundation. We thank Prof. H. Rapoport for useful discussions, and Dr. R. P. Philip and Mr. S. C. Brown for recording GC/MS data.

Abstract

5,6,7,8-Tetrahydroisoquinolines and other relatively inaccessible annelated pyridines (3) are now available by the reaction sequence (1) + (2)(3). This synthesis is much simpler and otherwise superior to previous methods.

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