Asymmetric Synthesis of α-Alkyl-α-aminocarboxylic Acids by Alkylation of 1-chiral-Substituted 2-Imidazolin-5-ones

Authors


  • Asymmetric Syntheses via Heterocyclic Intermediates, Part I.

Abstract

Over 95% asymmetric induction is achieved, given favorable substituent combinations, in the key step of a new synthesis of α-alkyl α-amino acids (1), X=H. Chemical yields are good, and the chiral auxiliary agent can be recovered.

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