4-Dialkylaminopyridines as Acylation Catalysts, Part 5.–Part 4: G. Höfle, W. Steglich, H. Vorbrüggen, Angew. Chem. and Angew. Chem. Int. Ed. Engl., in press.— We thank Prof. Vorbrüggen Schering AG, Berlin, for supplying the 4-dimethylaminopyridine.
1521-3773/asset/2002_left.gif?v=1&s=ac6b0d94a94d7ce7a210002b8096b42feffc0bcf)
1521-3773/asset/2002_right.gif?v=1&s=451042aa3415ae3ad0729984d26dee1866aca82e)
Communication
Simple Method for the Esterification of Carboxylic Acids†
Article first published online: 22 DEC 2003
DOI: 10.1002/anie.197805221
Copyright © 1978 by Verlag Chemie, GmbH, Germany
Issue
Angewandte Chemie International Edition in English
Volume 17, Issue 7, pages 522–524, July 1978
Additional Information
How to Cite
Neises, B. and Steglich, W. (1978), Simple Method for the Esterification of Carboxylic Acids. Angewandte Chemie International Edition in English, 17: 522–524. doi: 10.1002/anie.197805221
- †
Publication History
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- Manuscript Received: 24 APR 1978
- Abstract
- References
- Cited By
Addition of 4-dimethylaminopyridine (DMAP) accelerates the dicyclohexylcarbo-diimide (DCC)-activated esterification of carboxylic acids to such an extent that side reactions are eliminated and even sensitive acids such 2,5-cyclohexadiene-1-carboxylic acid readily form the tert-butyl ester. DMAP has so far been used mainly as acylation catalyst.
