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Molecular Structure of Phe2-TRH, an Analogue of Thyrotropin-Releasing Hormone

Authors

  • Dr. John J. Stezowski,

    Corresponding author
    1. Institut für Organische Chemie, Biochemie und Isotopenforschung der Universität Pfaffenwaldring 55, D-7000 Stuttgart 80 (Germany)
    • Institut für Organische Chemie, Biochemie und Isotopenforschung der Universität Pfaffenwaldring 55, D-7000 Stuttgart 80 (Germany)
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  • Dipl.-Chem. Claus Bürvenich,

    1. Institut für Organische Chemie der Universität, Auf der Morgenstelle 18, D-7400 Tübingen (Germany)
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  • Prof. Dr. Wolfgang Voelter

    1. Institut für Organische Chemie der Universität, Auf der Morgenstelle 18, D-7400 Tübingen (Germany)
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Abstract

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X-Ray structure analysis of thyrotropin-releasing hormone (TRH) has hitherto been precluded by the reluctance of TRH to crystallize. Suitable crystals of the closely related compounds Phe2-TRH have now been obtained. The structure of this compound is characterized by slight disorder (two conformations of the proline ring).

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