Key Building Blocks of Natural Product Biosynthesis and Their Significance in Chemistry and Medicine

Authors

  • Prof. Dr. Burchard Franck

    Corresponding author
    1. Organisch-Chemisches Institute der Universität, Orléans-Ring 23, D-4400 Münster (Germany)
    • Organisch-Chemisches Institute der Universität, Orléans-Ring 23, D-4400 Münster (Germany)
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  • Based on a plenary lecture given to the 110th Meeting of the Gesellschaft Deutscher Naturforscher und Ärzte on September 19, 1978 in Innsbruck (Austria).

Abstract

The principle features of the biosynthesis of natural products have been elucidated during the past thirty years by the use of isotopic methods. It was discovered that large groups of natural products originate from the same biosynthetic precursor—the key building block. The conversion of key building blocks into biologically active natural products serves as a model for the development of more efficient syntheses in chemistry. In medicine, information about key building blocks permits the elucidation and therapy of metabolic diseases.

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