Physicochemical Principles and Applications of Supercritical Fluid Chromatography (SFC). New analytical methods (19)

Authors

  • Dr. Ulrich van Wasen,

    1. Wasen Giulini Chemie GmbH, D-6700 Ludwigshafen (Germany)
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  • Dipl.-Chem. Issam Swaid,

    1. Lehrstuhl für Physikalische Chemie II der Universität, Postfach 102148, D-4630 Bochum 1 (Germany)
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  • Prof. Dr. Gerhard M. Schneider

    Corresponding author
    1. Lehrstuhl für Physikalische Chemie II der Universität, Postfach 102148, D-4630 Bochum 1 (Germany)
    • Lehrstuhl für Physikalische Chemie II der Universität, Postfach 102148, D-4630 Bochum 1 (Germany)
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  • Dedicated to Professor Ernst Ulrich Franck on the occasion of his 60th birthday

Abstract

In supercritical fluid chromatography (SFC) compressed gases in the region of their critical temperature are used as mobile phases. SFC has important advantages over gas chromatography (GC) for the separation of low-volatile or thermally unstable substances. Like high pressure liquid chromatography (HPLC) and gel chromatography, it is used for various special applications and preparative separations, e.g. in the petroleum industry and in the separation of oligomers. SFC is of great interest in fundamental research on fluid extraction and for the determination of the physicochemical properties of fluid systems. In this contribution the most important physicochemical, methodological, and instrumental principles of SFC are summarized; characteristic physicochemical applications are the determination of capacity ratios, partition coefficients, partial molar volumes, interaction second virial coefficients, and difusion coefficients.

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