Dedicated to Professor Ernst Ulrich Franck on the occasion of his 60th birthday
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Review
Physicochemical Principles and Applications of Supercritical Fluid Chromatography (SFC). New analytical methods (19)†
Article first published online: 22 DEC 2003
DOI: 10.1002/anie.198005753
Copyright © 1980 by Verlag Chemie, GmbH, Germany
Issue
Angewandte Chemie International Edition in English
Volume 19, Issue 8, pages 575–587, August 1980
Additional Information
How to Cite
van Wasen, U., Swaid, I. and Schneider, G. M. (1980), Physicochemical Principles and Applications of Supercritical Fluid Chromatography (SFC). New analytical methods (19). Angew. Chem. Int. Ed. Engl., 19: 575–587. doi: 10.1002/anie.198005753
- †
Publication History
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- Manuscript Received: 28 APR 1980
- Abstract
- References
- Cited By
Keywords:
- Supercritical fluid chromatography;
- Fluid chromatography;
- Analytical methods
Abstract
In supercritical fluid chromatography (SFC) compressed gases in the region of their critical temperature are used as mobile phases. SFC has important advantages over gas chromatography (GC) for the separation of low-volatile or thermally unstable substances. Like high pressure liquid chromatography (HPLC) and gel chromatography, it is used for various special applications and preparative separations, e.g. in the petroleum industry and in the separation of oligomers. SFC is of great interest in fundamental research on fluid extraction and for the determination of the physicochemical properties of fluid systems. In this contribution the most important physicochemical, methodological, and instrumental principles of SFC are summarized; characteristic physicochemical applications are the determination of capacity ratios, partition coefficients, partial molar volumes, interaction second virial coefficients, and difusion coefficients.