Photochemistry of Sulfonamides and Sulfonylureas: A Contribution to the Problem of Light-Induced Dermatoses


  • Dedicated to Professor Matthias Seefelder on the occasion of his 60th birthday


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Photochemical studies on model sulfonamides and antidiabetics(1) led to the conclusion that that appearance of light-induced dermatoses on administration of tolbutamide (1a) could be due to the reaction of radicals (and SO2) with the cell components; furthermore, (1a) might attack the cell protein as hapten.