Synthesis of [10-13C]Secologanin

Authors

  • Prof. Dr. Lutz-F. Tietze,

    Corresponding author
    1. Organisch-chemisches Institut der Universität, Tammannstrasse 2, D-3400 Göttngen (Germany)
    • Organisch-chemisches Institut der Univercitac Tammannstrasse 2, D-3400 Götingcn (Germany)
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  • Dipl.-Chem. Stephan Henke

    1. Organisch-chemisches Institut der Universität, Tammannstrasse 2, D-3400 Göttngen (Germany)
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  • This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie.

  • Dedicated to Professor Oskar Glemser on the occasion of his 70th birthday

Abstract

original image

Secologanin (1) plays a key role in the biogenesis of a series of alkaloids. Compound (1) labeled with 13C at position 10, which should enable identification of non-isolated intermediates, can be prepared from unlabeled (1), inter alia, via OsO4 and Pb(OAc)4-oxidation and a Wittig olefination.

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