The Ferrocenylmethyl(Fem) Group as a Highly Lipophilic and Chromophoric Group for the Masking of Peptide Bonds

Authors

  • Dr. Heiner Eckert,

    Corresponding author
    1. Organisch-chemisches Institut der Technischen Universität München, Lichtenbergstrasse 4, D-8046 Garching (FRG)
    • Organisch-chemisches Institut der Technischen Universität München, Lichtenbergstrasse 4, D-8046 Garching (FRG)
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  • Christoph Seidel

    1. Organisch-chemisches Institut der Technischen Universität München, Lichtenbergstrasse 4, D-8046 Garching (FRG)
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  • This work was supported by the Deutsche Forschungsgemeinschaft.

Abstract

original image

The ferrocenylmethyl (Fem) group may be used to influence the secondary structure of peptide derivatives. It can be incorporated directly and easily during the synthesis of peptides. The severe solubility problems often encountered in peptide chemistry can be solved by the use of the Fem group. Furthermore, its strong yellow color facilitates the preparative workup, especially the chromatographic purification, of the products.

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