Synthesis of the all-L-Configurated Cyclotetradepsipeptide cyclo[-L-Val-L-Lac-]2 by the Combined Protection/Activation Method with the 2,4-Bis(methylthio)phenoxycarbonyl Group

Authors

  • Prof. Dr. Horst Kunz,

    Corresponding author
    1. Institut für Organische Chemie der Universität, Johann-Joachim-Becher-Weg 18–20, D-6500 Mainz (FRG)
    • Institut für Organische Chemie der Universität, Johann-Joachim-Becher-Weg 18–20, D-6500 Mainz (FRG)
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  • Dr. Hans-Jürgen Lasowski

    1. Institut für Organische Chemie der Universität, Johann-Joachim-Becher-Weg 18–20, D-6500 Mainz (FRG)
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  • Dedicated to Professor Rolf C. Schulz on the occasion of his 65th birthday

Abstract

The first chemical cyclization of tetradepsipeptides such as 1, which contain only building blocks with the same configuration and without N-methyl groups, has been achieved with the new, activatable 2,4-(MeS)2C6H4[BOND]O[BOND]CO (Bmpc) protecting group. The initially formed cyclic mixed anhydride spontaneously eliminates CO2 to give 2.

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