The First Evidence of Endogenous Pyridoxyl Isoquinoline Alkaloids in Mammalian Organisms

Authors

  • Priv.-Doz. Dr. Gerhard Bringmann,

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    1. Organisch-chemisches Institut der Universität, Orléansring 23, D-4400 Münster (FRG)
    • Organisch-chemisches Institut der Universität, Orléansring 23, D-4400 Münster (FRG)
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  • Dr. Stephan Schneider

    1. Organisch-chemisches Institut der Universität, Orléansring 23, D-4400 Münster (FRG)
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  • Endogenous Alkaloids in Humans, Part 2. This work was supported by the Minister für Wissenschaft und Forschung des Landes Nordrhein-Westfalen and by the Fonds der Chemischen Industrie (a grant and a fellowship for S. S.). We thank Priv.-Doz. Dr. K. D. Richter, Zentrale Tierexperimentelle Einrichtung der Universitätskliniken Münster, for valuable suggestions and Dipl.-Chem. M. Zsiška for experimental assistance in the animal experiments. Part 1: G. Bringmann, Naturwissen-schaften 66 (1979) 22.

Abstract

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The “animal alkaloids” 1, R[DOUBLE BOND]H, CO2H, can be detected in rats after intravenous administration of therapeutically common doses of vitamin B6 (pyridoxine) and L-dopa. To accomplish this, it was necessary to develop a method for the analysis of extremely polar substances.

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