Synthesis of N-(1-Carboxy-5-aminopentyl)dipeptides as Inhibitors of Angiotensin Converting Enzyme

Authors

  • Lebensmittelchem. Rüdiger Escher,

    1. Biochemisches Institut der Universität, Hermann-Herder-Str. 7, D-7800 Freiburg (FRG)
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  • Priv.-Doz. Dr. Peter Bünning

    Corresponding author
    1. Biochemisches Institut der Universität, Hermann-Herder-Str. 7, D-7800 Freiburg (FRG)
    • Biochemisches Institut der Universität, Hermann-Herder-Str. 7, D-7800 Freiburg (FRG)
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  • This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie. We wish to thank Dr. H. Urbach, Dr. R. Henning. Dr. F. Effenberger, and Mrs. U. Burkard for their valuable help with this work.

Abstract

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Excellent ligands for an affinity chromatography of angiotensin converting enzyme have been found, namely the new inhibitors of this enzyme such as 1, R1, R2[DOUBLE BOND]H, alkyl. They were prepared from Nε-Boc-L-lysine methyl ester and α;-trifluoromethanesulfonyloxycarboxylic esters. Inhibitors of this enzyme are of pharmaceutical importance.

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