This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie. We wish to thank Dr. H. Urbach, Dr. R. Henning. Dr. F. Effenberger, and Mrs. U. Burkard for their valuable help with this work.
Synthesis of N-(1-Carboxy-5-aminopentyl)dipeptides as Inhibitors of Angiotensin Converting Enzyme†
Article first published online: 22 DEC 2003
Copyright © 1986 by VCH Verlagsgesellschaft mbH, Germany
Angewandte Chemie International Edition in English
Volume 25, Issue 3, pages 277–278, March 1986
How to Cite
Escher, R. and Bünning, P. (1986), Synthesis of N-(1-Carboxy-5-aminopentyl)dipeptides as Inhibitors of Angiotensin Converting Enzyme. Angew. Chem. Int. Ed. Engl., 25: 277–278. doi: 10.1002/anie.198602771
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- Manuscript Revised: 2 JAN 1986
- Manuscript Received: 6 NOV 1985
Excellent ligands for an affinity chromatography of angiotensin converting enzyme have been found, namely the new inhibitors of this enzyme such as 1, R1, R2H, alkyl. They were prepared from Nε-Boc-L-lysine methyl ester and α;-trifluoromethanesulfonyloxycarboxylic esters. Inhibitors of this enzyme are of pharmaceutical importance.