Enzyme-Catalyzed Cyanohydrin Synthesis in Organic Solvents

Authors

  • Prof. Dr. Franz Effenberger,

    Corresponding author
    1. Institut für Organische Chemie der Universität Pfaffenwaldring 55, D-7000 Stuttgart 80 (FRG)
    • Institut für Organische Chemie der Universität Pfaffenwaldring 55, D-7000 Stuttgart 80 (FRG)
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  • Dr. Thomas Ziegler,

    1. Institut für Organische Chemie der Universität Pfaffenwaldring 55, D-7000 Stuttgart 80 (FRG)
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  • Dr. Siegfried Förster

    1. Institut für Organische Chemie der Universität Pfaffenwaldring 55, D-7000 Stuttgart 80 (FRG)
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Abstract

original image

A substantial suppression of the chemical reaction in favor of the enzymatic reaction has been achieved in the addition of hydrogen cyanide to aldehydes. This reaction with mandelonitrile lyase (“(R)-oxynitrilase”) in ethyl acetate affords the cyanohydrins 3 with up to 99% ee; in H2O/EtOH, maximally 86% ee was achieved.

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