A Synthetic Molecular Trefoil Knot

Authors

  • Dr. Christiane O. Dietrich-Buchecker,

    1. Laboratoire de Chimie Organo-Minérale, UA 422 au CNRS, Institut de Chimie, Université Louis Pasteur 1, rue Blaise Pascal, F-67000 Strasbourg (France)
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  • Dr. Jean-Pierre Sauvage

    Corresponding author
    1. Laboratoire de Chimie Organo-Minérale, UA 422 au CNRS, Institut de Chimie, Université Louis Pasteur 1, rue Blaise Pascal, F-67000 Strasbourg (France)
    • Laboratoire de Chimie Organo-Minérale, UA 422 au CNRS, Institut de Chimie, Université Louis Pasteur 1, rue Blaise Pascal, F-67000 Strasbourg (France)
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  • The work was supported by the CNRS. We express our gratitude to A. Van Dorsselaer, F. Bitsch and R. Hueber, for mass spectroscopy experiments and fruitful discussions. The important contribution of J. P. Kintzinger and P. Maltese to the NMR studies is also warmly acknowledged.

Abstract

original image

Molecular knots have long been the subject of speculation. Now, for the first time, it has been possible to synthesize a “knotted” molecule having the topological chirality of a trefoil knot. Compound 1 was synthesized via a double-helix complex by exploiting the template effect of CuI ions. The chirality of 1 could be demonstrated by 1H NMR spectroscopy. The “unraveled” topological isomer of 1 was also synthesized.

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