NaBH4 Reduction of Ketones in the Solid State

Authors

  • Prof. Fumio Toda,

    1. Department of Industrial Chemistry, Faculty of Engineering, Ehime University, Matsuyama 790 (Japan)
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  • Koji Kiyoshige,

    Corresponding author
    1. Department of Industrial Chemistry, Faculty of Engineering, Ehime University, Matsuyama 790 (Japan)
    • Department of Industrial Chemistry, Faculty of Engineering, Ehime University, Matsuyama 790 (Japan)
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  • Minoru Yagi

    1. Department of Industrial Chemistry, Faculty of Engineering, Ehime University, Matsuyama 790 (Japan)
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Abstract

original image

Without solvent, merely by rubbing the solid reactants in an agate mortar, it was possible to reduce more than just simple ketones with NaBH4; even regio- and enantioselective reductions could be achieved when inclusion complexes were used. The hydroxyketones 2 and 4, which are of interest as synthetic building blocks, were prepared from the ketones 1 and 3, respectively.

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