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Keywords:

  • Drug research;
  • Syntopic antagonism;
  • Nobel lecture;
  • Hormone antagonists
Thumbnail image of graphical abstract

Hormones as prototypes in the development of drugs; this was the theme of the lecture by the third recipient of the 1988 Nobel Prize in Medicine, whose research led to compounds such as propranolol 1, derived from adrenaline andused as a drug against angina pectoris illnesses, and burimamide 2, derived from histamine, used against increased gastric secretion, the cause of stomach and duodenal ulcers.