Drugs from Emasculated Hormones: The Principle of Syntopic Antagonism (Nobel Lecture)

Authors

  • Prof. Sir James W. Black

    Corresponding author
    1. James Black Foundation, King's College School of Medicine and Dentistry, 68 Half Moon Lane, Dulwich, GB-London SE24 9 JE (UK)
    • James Black Foundation, King's College School of Medicine and Dentistry, 68 Half Moon Lane, Dulwich, GB-London SE24 9 JE (UK)
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  • Copyright © The Nobel Foundation 1989. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.

Abstract

original image

Hormones as prototypes in the development of drugs; this was the theme of the lecture by the third recipient of the 1988 Nobel Prize in Medicine, whose research led to compounds such as propranolol 1, derived from adrenaline andused as a drug against angina pectoris illnesses, and burimamide 2, derived from histamine, used against increased gastric secretion, the cause of stomach and duodenal ulcers.

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