This work was supported by the National Institute of Health.
Chain-Substituted Lipids as Substrates for Phospholipase A2†
Article first published online: 30 DEC 2003
Copyright © 1989 by VCH Verlagsgesellschaft mbH, Germany
Angewandte Chemie International Edition in English
Volume 28, Issue 9, pages 1218–1219, September 1989
How to Cite
Menger, F. M. and Wood, M. G. (1989), Chain-Substituted Lipids as Substrates for Phospholipase A2. Angew. Chem. Int. Ed. Engl., 28: 1218–1219. doi: 10.1002/anie.198912181
- Issue published online: 30 DEC 2003
- Article first published online: 30 DEC 2003
- Manuscript Received: 20 FEB 1989
More stable liposomes for drug delivery, and substances for controlling prostaglandin levels, may result from the interesting observation reported here: phospholipids like 1, which contain bulky alkyl substituents in the first half of their fatty acid residues, are much less readily hydrolyzed by phospholipase A2 than distearoylphosphatidylcholine itself.