A New Class of DNA-Cleaving Molecules: pH-Dependent DNA Cleavage by Propargylic and Allenic Sulfones


  • This work was supported by the National Science Foundation, the National Institutes of Health, and the University of Pennsylvania.


original image

DNA-cleaving agents are of considerable interest in molecular biology and pharmaceutical chemistry. The Garrett–Braverman reaction sequence has now been utilized as a basis for developing the title compounds; l3 are examples. They are capable of cleaving ϕX174 DNA in a pH-dependent reaction with maximal activity at pH 8.5.