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Synthesis and Pharmacological Properties of a Novel Cardioactive Steroid

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  • This work was supported by the Deutsche Forschungsgemeinschaft (We 595/12-3, researcher group “Konzell”) and the Fonds der Chemischen Industrie.

Abstract

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How do cardioactive steroid lactones exert their effects? It is known that they inhibit Na/K ATPase, an enzyme that serves in the active transport of Na and K across the plasma membrane. To determine where the steroid lactones bind on the enzyme, a flexible synthetic route to compounds of type 1 was developed. The goal was to obtain substances containing a reactive R group. The parent compound 1, R [DOUBLE BOND] H, inhibits the Na/K ATPase and exerts a positive inotropic effect.

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