This work was supported by the Studienstiftung des Deutschen Volkes and the Stiftung Stipendien-Fonds des Verbandes der Chemischen Industrie.
A New Strategy for Solid-Phase Synthesis of O-Glycopeptides†
Article first published online: 22 DEC 2003
Copyright © 1992 by VCH Verlagsgesellschaft mbH, Germany
Angewandte Chemie International Edition in English
Volume 31, Issue 7, pages 857–859, July 1992
How to Cite
Bielfeldt, T., Peters, S., Meldal, M., Bock, K. and Paulsen, H. (1992), A New Strategy for Solid-Phase Synthesis of O-Glycopeptides. Angew. Chem. Int. Ed. Engl., 31: 857–859. doi: 10.1002/anie.199208571
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- Manuscript Received: 25 JAN 1992
By direct glycoside synthesis, activated glycosyl amino acids are accessible. They can be utilized in the solid-phase synthesis for the preparation of glycopeptides with 2-azido-2-deoxy-D-galactose residues. The transformation into the acetamido derivatives and the subsequent deblocking occur on the polymeric support. This method is quite powerful, as the synthesis of the pentaglycosidated octapeptide shown below proves.