This work was supported by the Leonhard-Lorenz-Stiftung and Hoechst AG, and was presented at the seventh European Carbohydrate Symposium 1993 in Krakow (Poland). I thank Prof. Horst Kessler for his generous support.
Synthesis of a Biantennary Heptasaccharide by Regioselective Glycosylations†
Article first published online: 22 DEC 2003
Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany
Angewandte Chemie International Edition in English
Volume 33, Issue 10, pages 1102–1104, June 6, 1994
How to Cite
Unverzagt, C. (1994), Synthesis of a Biantennary Heptasaccharide by Regioselective Glycosylations. Angew. Chem. Int. Ed. Engl., 33: 1102–1104. doi: 10.1002/anie.199411021
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- Manuscript Received: 20 DEC 1993
A single protective group is sufficient at β-mannoside for the selective introduction of both side chains of A. The key glycosylations at the branching point proceed with high regioselectivity when 4,6-O-benzylidene acetal is used as a temporary protecting group. Protected heptasaccharide A was synthesized as a precursor of the undecasaccharide-asparagine found on glycoproteins and shown below.