Advertisement

A Convergent Synthesis of 2,5-trans-Linked Oligo (tetrahydrofuran)s: Potential Building Blocks for a Polyether Helix with Ion Channel Activity

Authors

  • Dr. Ulrich Koert,

    Corresponding author
    1. Fachbereich Chemie der Universität, Hans-Meerwein-Strasse, D-35043 Marburg (FRG), Telefax: Int. code + (6421)288917
    • Fachbereich Chemie der Universität, Hans-Meerwein-Strasse, D-35043 Marburg (FRG), Telefax: Int. code + (6421)288917
    Search for more papers by this author
  • Dipl.-Chem. Matthias Stein,

    1. Fachbereich Chemie der Universität, Hans-Meerwein-Strasse, D-35043 Marburg (FRG), Telefax: Int. code + (6421)288917
    Search for more papers by this author
  • Dr. Klaus Harms

    1. Fachbereich Chemie der Universität, Hans-Meerwein-Strasse, D-35043 Marburg (FRG), Telefax: Int. code + (6421)288917
    Search for more papers by this author

  • This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie. We thank Wacker AG and BASF AG for donations of chemicals. M. S. thanks the Studienstiftung des Deutschen Volkes for a graduate fellowship.

Abstract

original image

The C2-symmetric tetrahydrofuran pentamer 1 was prepared in enantiomerically pure form by a convergent synthesis. Compounds of this type are of interest for the construction of synthetic ion channels from polyether helices. TBDPS = tBuPh2Si.

Ancillary