This work was supported by The Robert Welch Foundation and The National Science Foundation. K. B. thanks The National Institutes of Health for a Career Development Award, and the Alfred P. Sloan Foundation.
A Reagent for Determining Optical Purities of Diols by Formation of Diastereomeric Arylboronate Esters†
Article first published online: 22 DEC 2003
Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany
Angewandte Chemie International Edition in English
Volume 33, Issue 11, pages 1182–1184, June 22, 1994
How to Cite
Burgess, K. and Porte, A. M. (1994), A Reagent for Determining Optical Purities of Diols by Formation of Diastereomeric Arylboronate Esters. Angew. Chem. Int. Ed. Engl., 33: 1182–1184. doi: 10.1002/anie.199411821
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- Manuscript Received: 19 JAN 1994
A remarkably simple arylboronic acid reagent for derivatization of diols enables the determination of the optical purity of diols by 1H NMR spectroscopy by the formation of the corresponding esters 1. This procedure could be particularly valuable as enantioselective bishydroxylations become more widely used for asymmetric syntheses.