Template Effects in New Self-Replicating Molecules

Authors

  • M. Morgan Conn,

    1. Department of Chemistry, Massachusetts Institute of Technology Cambridge, MA 02139 (USA) Telefax: Int. code + (617)253-7929
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  • Edward A. Wintner,

    1. Department of Chemistry, Massachusetts Institute of Technology Cambridge, MA 02139 (USA) Telefax: Int. code + (617)253-7929
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  • Prof. Dr. Julius Rebek Jr.

    Corresponding author
    1. Department of Chemistry, Massachusetts Institute of Technology Cambridge, MA 02139 (USA) Telefax: Int. code + (617)253-7929
    • Department of Chemistry, Massachusetts Institute of Technology Cambridge, MA 02139 (USA) Telefax: Int. code + (617)253-7929
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  • This work was supported by the National Science Foundation (NSF) (Grant No. 9119995-CHE). M. M. C. thanks the National Science and Engineering Research Council (NSERC) and E. A. W. the NSF for predoctoral fellowships.

Abstract

original image

The whole is greater than the sum of its parts-this adage holds for the new replication system composed of 1 and 2, which features a very high affinity between complementary components. In this system all reactions proceed via complexes, which minimizes the effects of background reactions. The autocatalysis displayed by the system is shown to arise solely from template effects. R = [BOND]C6H4[BOND]C6H4[BOND]COOC6F5.

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