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Biosynthetic Investigations on Pyridazomycin

Authors

  • Dr. Heike Bockholt,

    1. Institut für Organische Chemie der Universität, Tammannstrasse 2, D-37077 Göttingen (FRG), Telefax: Int. code + (551)39-9660
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  • Prof. Dr. John M. Beale,

    1. Institute for Medicinal and Natural Product Chemistry, College of Pharmacy, University of Texas, Austin, TX, 78712 (USA)
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  • Priv.-Doz. Dr. Jürgen Rohr

    Corresponding author
    1. Institut für Organische Chemie der Universität, Tammannstrasse 2, D-37077 Göttingen (FRG), Telefax: Int. code + (551)39-9660
    • Institut für Organische Chemie der Universität, Tammannstrasse 2, D-37077 Göttingen (FRG), Telefax: Int. code + (551)39-9660
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  • This work was supported by the Deutsche Forschungsgemeinschaft, the Fonds der Chemischen Industrie, and NATO.

  • Dedicated to Professor Heinz G.Floss on the occasion of his birthday

Abstract

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An unexpected amino acid metabolism is used by a subspecies of the soil bacterium Streptomyces violaceoniger to produce the antifungal antibiotic pyridazomycin 1-C1. Feeding studies with isotopically labeled precursors indicate that 1 is constructed from ornithine, glycine, and probably oxaloacetate.

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