Molecular Golf Balls: Vesicles from Bowl-Shaped Host Molecules

Authors

  • Dipl.-Chem. Albertus P. H. J. Schenning,

    1. Department of Organic Chemistry, NSR Center, University of Nijmegen, Toernooiveld, NL-6525 ED Nijmegen (The Netherlands), Telefax: Int. code + (31)80-55-34-50
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  • Bas de Bruin,

    1. Department of Organic Chemistry, NSR Center, University of Nijmegen, Toernooiveld, NL-6525 ED Nijmegen (The Netherlands), Telefax: Int. code + (31)80-55-34-50
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  • Dr. Martinus C. Feiters,

    Corresponding author
    1. Department of Organic Chemistry, NSR Center, University of Nijmegen, Toernooiveld, NL-6525 ED Nijmegen (The Netherlands), Telefax: Int. code + (31)80-55-34-50
    • Department of Organic Chemistry, NSR Center, University of Nijmegen, Toernooiveld, NL-6525 ED Nijmegen (The Netherlands), Telefax: Int. code + (31)80-55-34-50
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  • Prof. Dr. Roeland J. M. Nolte

    Corresponding author
    1. Department of Organic Chemistry, NSR Center, University of Nijmegen, Toernooiveld, NL-6525 ED Nijmegen (The Netherlands), Telefax: Int. code + (31)80-55-34-50
    • Department of Organic Chemistry, NSR Center, University of Nijmegen, Toernooiveld, NL-6525 ED Nijmegen (The Netherlands), Telefax: Int. code + (31)80-55-34-50
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  • This work was supported by Netherlands Foundation for Chemical Research (SON) with financial aid from the Netherlands Organization for Scientific Research (NWO).

Abstract

original image

Vesicles with concave binding sites on the surface form when the bowlshaped amphiphile 1 is dispersed in water. The dimples on the outer surface of these molecular “golf balls” strongly bind guest molecules (association constant Ka = 4 × 105M−1).

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