Communication

Synthesis of a New Unnatural Amino Acid with a Benzodiazepine-Containing Side Chain and Incorporation into a Tripeptide

  1. Prof. Johann Mulzer1,*,
  2. Dr. Fridtjof Schröder1,
  3. Dr. Alessandro Lobbia2,
  4. Jürgen Buschmann3,
  5. Peter Luger3

Article first published online: 22 DEC 2003

DOI: 10.1002/anie.199417371

Issue

Angewandte Chemie International Edition in English

Angewandte Chemie International Edition in English

Volume 33, Issue 17, pages 1737–1739, September 16, 1994

Additional Information

How to Cite

Mulzer, J., Schröder, F., Lobbia, A., Buschmann, J. and Luger, P. (1994), Synthesis of a New Unnatural Amino Acid with a Benzodiazepine-Containing Side Chain and Incorporation into a Tripeptide. Angew. Chem. Int. Ed. Engl., 33: 1737–1739. doi: 10.1002/anie.199417371

Author Information

  1. 1

    Institut für Organische Chemie der Freien Universität, Takustrasse 3, D-14195 Berlin (FRG), Telefax: Int. code + (30)838-5163

  2. 2

    Schering AG, Berlin (FRG)

  3. 3

    Institut für Kristallographie der Freien Universität Berlin (FRG)

*Institut für Organische Chemie der Freien Universität, Takustrasse 3, D-14195 Berlin (FRG), Telefax: Int. code + (30)838-5163

Publication History

  1. Issue published online: 22 DEC 2003
  2. Article first published online: 22 DEC 2003
  3. Manuscript Received: 12 MAR 1994

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Peptidomimetics based on benzodiazepines can be made from nonnatural amino acids such as 1. They can function both as peptidic and nonpeptidic receptor ligands, owing to the modified amino acid side chains. Compound 1 was synthesized from monomethyl L-glutamate in seven steps in 15% overall yield.

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