A Novel Approach to the Stereoselective Synthesis of β-Mannosides

Authors

  • Dr. Yukishige Ito,

    1. The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama 351-01 (Japan), Telefax: Int. code + (48)462-4680
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  • Prof. Dr. Tomoya Ogawa

    Corresponding author
    1. The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama 351-01 (Japan), Telefax: Int. code + (48)462-4680
    • The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama 351-01 (Japan), Telefax: Int. code + (48)462-4680
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    • Alternative address: Department of Cellular Biochemistry, Faculty of Agriculture, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113 (Japan)


Abstract

original image

A simple procedure and compatibility with a variety of manipulations encountered in oligosaccharide synthesis–these advantages are features of this stereoselective synthesis of β-mannosides. The acetal 2 was obtained smoothly from the protected fluoride 1. Subsequent activation of the anomeric position afforded β-mannoside stereoselectively in good yields. CH2X = p-methoxybenzyl.

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