Diastereomerically Pure Mannich Bases from the Addition of Enamines to Ternary Iminium Salts

Authors

  • Prof. Dr. Nikolaus Risch,

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    1. Fachbereich Chemie und Chemietechnik der Universität-Gesamthochschule Warburger Strasse 100, D-33098 Paderborn (FRG) Telefax: Int. code + (5251)60-3245
    • Fachbereich Chemie und Chemietechnik der Universität-Gesamthochschule Warburger Strasse 100, D-33098 Paderborn (FRG) Telefax: Int. code + (5251)60-3245
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  • Dipl.-Chem. Michael Arend

    1. Fachbereich Chemie und Chemietechnik der Universität-Gesamthochschule Warburger Strasse 100, D-33098 Paderborn (FRG) Telefax: Int. code + (5251)60-3245
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  • Stereoselective Synthesis of Mannich Bases, Part 2. This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie. Part 1:[1].

Abstract

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Very high yields and diastereoselectivities, mild reaction conditions, a straightforward experimental procedure, and cheap starting materials—these are the advantages offered by the reaction of (E)-enamines 1 with iminium salts 2 to give the Mannich bases 3. Since Mannich bases are important synthetic building blocks for Pharmaceuticals and natural products, this reaction will surely prove to be extremely useful.

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