A Short Route to [3-15N]-3′-Azido-3′-deoxythymidine (N3-Labeled AZT) via 3-Nitro-AZT

Authors

  • Xavier Ariza,

    1. Departament de Química Orgànica, Universität de Barcelona E-08028 Barcelona (Catalonia, Spain) Telefax: Int. code + (3)339-7878
    Search for more papers by this author
  • Dr. Valentí Bou,

    1. Departament de Química Orgànica, Universität de Barcelona E-08028 Barcelona (Catalonia, Spain) Telefax: Int. code + (3)339-7878
    Search for more papers by this author
  • Prof. Jaume Vilarrasa,

    Corresponding author
    1. Departament de Química Orgànica, Universität de Barcelona E-08028 Barcelona (Catalonia, Spain) Telefax: Int. code + (3)339-7878
    • Departament de Química Orgànica, Universität de Barcelona E-08028 Barcelona (Catalonia, Spain) Telefax: Int. code + (3)339-7878
    Search for more papers by this author
  • Dr. Valya Tereshko,

    1. Departament d'Enginyeria Química, Universitat Politècnica E-08028 Barcelona (Catalonia, Spain)
    Search for more papers by this author
    • X-ray structure analysis

  • Dr. J. L. Campos

    1. Departament d'Enginyeria Química, Universitat Politècnica E-08028 Barcelona (Catalonia, Spain)
    Search for more papers by this author
    • X-ray structure analysis


  • This research was supported by the Dirección General de Investigatión Científica y Técnica (Grants PB86-0137 and PB89-0277 to the Universität de Barcelona, and Grant PB90-0605 to the Universitat Politècnica) and by the Ministerio de Educatión y Ciencia (fellowships to V. B. and X. A).

Abstract

original image

Nucleosides with appropriate isotopic labels are crucial for studies of nucleic acid structures, drug-binding phenomena, and related molecular recognition processes. A mild and general approach for the introduction of 15N at the 3-position of pyrimidine nucleosides is illustrated by the conversion of AZT to [3-15N]-AZT 1 (* = isotopically labeled).

Ancillary