I thank Sigrid Eckardt, Matthias Homann, and Volker Patzel for critical reading of the manuscript.
The Three-Dimensional Structure of Hammerhead Ribozymes†
Article first published online: 22 DEC 2003
Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany
Angewandte Chemie International Edition in English
Volume 34, Issue 6, pages 643–645, March 31, 1995
How to Cite
Sczakiel, G. (1995), The Three-Dimensional Structure of Hammerhead Ribozymes. Angew. Chem. Int. Ed. Engl., 34: 643–645. doi: 10.1002/anie.199506431
- Issue published online: 22 DEC 2003
- Article first published online: 22 DEC 2003
- structural elucidation
Two methods—one result: Through fluorescence energy transfer measurements and an X-ray structure analysis on ribozyme–substrate complexes, the groups of Eckstein and McKay independently arrived at a largely consistent structural model for hammerhead ribozymes. Three helices are arranged in a stretched Y shape (see picture) and are stabilized by unusual interactions besides the Watson-Crick base pairing.