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Keywords:

  • biochemistry;
  • ribozymes;
  • metalloenzymes;
  • RNA;
  • structural elucidation
Thumbnail image of graphical abstract

Two methods—one result: Through fluorescence energy transfer measurements and an X-ray structure analysis on ribozyme–substrate complexes, the groups of Eckstein and McKay independently arrived at a largely consistent structural model for hammerhead ribozymes. Three helices are arranged in a stretched Y shape (see picture) and are stabilized by unusual interactions besides the Watson-Crick base pairing.