Remarkably high chemo- and regioselectivity was found in the intramolecular one-pot McMurray-type reaction between ketone and amide carbonyl groups. A simple preparative method is used by which the active low-valent titanium species is formed selectively at the site of the reductive coupling. For example, compound 2 is formed from 1 in 86% yield by a zipper-like series of carbonyl couplings.
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