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Keywords:

  • solid-phase synthesis;
  • glycopeptide;
  • peptide
Thumbnail image of graphical abstract

An efficient solid-phase synthesis of glycopeptides is achieved with the new anchor HYCRON, which combines an allylic ester with the flexible, solubilizing triethyleneglycol spacer. Acid- and base-stability of the allylic anchor enables both Fmoc and Boc strategies to be used. The partially protected glycopeptides can be cleaved from the support by Pd0 catalysis under virtually neutral conditions in high yields (about 95%) and purity (>95%). AMPS = aminomethylpolystyrene.